Description

2(S)-4-Benzoyloxy Carbonyl-2-Phthalimido Butyryl Chloride CAS NO 88767-16-2 is a high-purity, chiral organic intermediate characterized by its reactive acid chloride functional group. This compound is critically important for the synthesis of complex, optically active molecules, particularly in the development of pharmaceuticals and advanced materials. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for constructing peptide-like backbones and other sophisticated molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for chiral drugs targeting neurological and metabolic disorders.
• Peptidomimetic Synthesis: Used to introduce protected amino acid derivatives into peptide chains, enabling the creation of novel peptidomimetics for drug discovery.
• Agrochemical Research: Serves as a precursor in developing chiral herbicides, fungicides, and plant growth regulators with enhanced efficacy and selectivity.
• Custom Synthesis & Contract Manufacturing: Employed by CDMOs (Contract Development and Manufacturing Organizations) for custom, multi-step synthesis projects requiring high stereochemical purity.
• Academic & Industrial R&D: Utilized in research laboratories for exploring new synthetic methodologies and creating libraries of chiral compounds for screening.
• Specialty Polymer Modification: Acts as a functional monomer or cross-linking agent for creating polymers with specific chiral or reactive sites.

Basic Information

Product Name	2(S)-4-Benzoyloxy Carbonyl-2-Phthalimido Butyryl Chloride
CAS No.	88767-16-2
Molecular Formula	C20H14ClNO6
Molecular Weight	399.78 g/mol
Synonyms	(2S)-4-(Benzoyloxy)-1-chloro-1,4-dioxo-2-(1,3-dioxoisoindol-2-yl)butan-2-yl benzoate; 2(S)-4-(Benzoyloxy)-2-phthalimidobutanoyl chloride; (S)-4-(Benzoyloxy)-2-(1,3-dioxoisoindolin-2-yl)-4-oxobutanoic acid chloride; N-[(Benzyloxy)carbonyl]-L-aspartic acid β-benzyl ester N-carboxyanhydride (related precursor); Boc-Asp(OBzl)-OSu derivative (related protected form); Z-Asp(OBzl)-Cl; L-Aspartic acid derivative, 4-benzyl ester, N-phthaloyl, chloride
EINECS	Contact for details

Quality Control

Our 2(S)-4-Benzoyloxy Carbonyl-2-Phthalimido Butyryl Chloride is manufactured under strict quality systems to ensure batch-to-batch consistency and high chiral purity. Each lot undergoes rigorous analytical testing, including chiral HPLC, NMR, and IR spectroscopy, to confirm identity, purity, and enantiomeric excess. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP guidelines where applicable to support our customers in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.