Description

Pyrazinecarbonyl Chloride, 5-Chloro- (9Ci) is a high-purity, reactive heterocyclic building block essential for advanced organic synthesis. This compound matters for its role as a key acylating agent and intermediate in the development of complex molecules with specific pharmacological or agrochemical activities. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and infectious diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the pyrazine core contributes to biological activity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of organic semiconductors, conductive polymers, and other advanced functional materials.
• Peptide Mimetics and Bioconjugation: The reactive acid chloride group is utilized for coupling reactions to create peptide analogs or for bioconjugation strategies.
• Custom Synthesis and Contract Manufacturing: A valuable building block for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	Pyrazinecarbonyl Chloride, 5-Chloro- (9Ci)
CAS No.	88625-23-4
Molecular Formula	C5H2Cl2N2O
Molecular Weight	176.99 g/mol
Synonyms	5-Chloropyrazine-2-carbonyl chloride; 5-Chloropyrazinecarbonyl chloride; 2-Chlorocarbonyl-5-chloropyrazine; 5-Chloro-2-pyrazinecarbonyl chloride; 5-Chloropyrazinoyl chloride; 5-Chloro-pyrazine-2-carboxylic acid chloride; 88625-23-4
EINECS	Contact for details

Quality Control

Every batch of Pyrazinecarbonyl Chloride, 5-Chloro- (9Ci) is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements of your synthesis. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and conformity to agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.