Description

9-(6-(4-Azidobenzamido)Hexylamino)Acridine is a specialized, bifunctional chemical probe designed for advanced bioconjugation and labeling applications. Its molecular architecture, featuring an acridine fluorophore linked to a photoactivatable aryl azide via a hexylamino spacer, provides unique capabilities for crosslinking and detection in complex biological systems. This compound is essential for researchers and developers in pharmaceutical R&D, proteomics, and diagnostic assay development who require precise, covalent tagging of biomolecules.

Application

• Photoaffinity Labeling: Used as a critical reagent for mapping protein-ligand interaction sites and identifying biological targets through covalent crosslinking upon UV irradiation.
• Fluorescent Probe Synthesis: Serves as a key intermediate for creating custom fluorescent tags and sensors for cellular imaging and flow cytometry.
• Bioconjugation & Linker Chemistry: Employed to develop antibody-drug conjugates (ADCs) or other targeted therapeutic constructs by linking payloads to targeting moieties.
• Nucleic Acid Research: Applied in the study of DNA and RNA structures and interactions, utilizing its intercalating acridine moiety and reactive azide group.
• Material Surface Functionalization: Used to modify surfaces (e.g., chips, nanoparticles) with photoreactive groups for subsequent immobilization of biomolecules.
• Chemical Biology Tool Development: A foundational building block for creating novel chemical tools to probe enzyme activity, protein trafficking, and other dynamic cellular processes.

Basic Information

Product Name	9-(6-(4-Azidobenzamido)Hexylamino)Acridine
CAS No.	88373-10-8
Molecular Formula	C26H27N7O
Molecular Weight	453.54 g/mol
Synonyms	N-(6-((9-Acridinyl)amino)hexyl)-4-azidobenzamide; 4-Azido-N-[6-[(9-acridinyl)amino]hexyl]benzamide; 9-[6-[(4-Azidobenzoyl)amino]hexylamino]acridine; Acridine, 9-[6-[(4-azidobenzoyl)amino]hexylamino]-; Photoactivatable Acridine Probe; AHA Probe; Acridine-aryl azide crosslinker
EINECS	Contact for details

Quality Control

Our production of 9-(6-(4-Azidobenzamido)Hexylamino)Acridine adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and the integrity of the photoreactive azide group. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and thermal degradation. Allow the container to reach room temperature in a desiccator before opening to prevent condensation and moisture uptake. This material is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere).

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.