Description

2(1H)-Pyrimidinone, 1-(2-Deoxy-5-o-(Hydroxy((Hydroxy(Phosphonooxy)Phosphinyl)Oxy)Phosphinyl)-β-D-Erythro-Pentofuranosyl)-4-Methoxy- is a chemically modified nucleoside analog of significant interest in advanced pharmaceutical research and development. This compound matters as a sophisticated building block for the synthesis of nucleotide prodrugs and modified oligonucleotides, enabling targeted therapeutic strategies. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of antiviral agents, anticancer therapies, and novel molecular biology tools.

Application

• Antiviral Drug Development: A key intermediate in the synthesis of nucleotide analogs targeting viral polymerases.
• Oncology Research: Used in the creation of prodrugs designed to inhibit cancer cell proliferation.
• Oligonucleotide Synthesis: Serves as a modified phosphoramidite precursor for introducing specific functionalities into DNA/RNA sequences.
• Biochemical Probes: Utilized in the development of labeled nucleotides for diagnostic assays and mechanistic studies.
• Pharmaceutical Intermediates: A critical raw material for the cGMP manufacturing of active pharmaceutical ingredients (APIs).
• Academic & Industrial R&D: Fundamental research into nucleotide metabolism, enzyme mechanisms, and structure-activity relationships.

Basic Information

Product Name	2(1H)-Pyrimidinone, 1-(2-Deoxy-5-o-(Hydroxy((Hydroxy(Phosphonooxy)Phosphinyl)Oxy)Phosphinyl)-β-D-Erythro-Pentofuranosyl)-4-Methoxy-
CAS No.	88254-09-5
Molecular Formula	C10H17N2O14P3
Molecular Weight	482.16 g/mol
Synonyms	4-Methoxy-2(1H)-pyrimidinone 1-(2-deoxy-5-O-{hydroxy[hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl-β-D-erythro-pentofuranoside); 1-(2-Deoxy-5-O-{hydroxy[hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl-β-D-erythro-pentofuranosyl)-4-methoxypyrimidin-2(1H)-one; 4-Methoxypyrimidin-2(1H)-one nucleotide triphosphate analog; Modified Nucleoside Triphosphate; Nucleotide Prodrug Intermediate; Phosphorylated Nucleoside Analog
EINECS	Contact for details

Quality Control

Our 2(1H)-Pyrimidinone nucleotide analog is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support development projects requiring material aligned with cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive) and must be handled under anhydrous conditions or a dry inert atmosphere to maintain stability. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.