Description

Myxopyronin B is a potent, naturally derived antibiotic compound belonging to the myxopyronin class, which functions as a selective inhibitor of bacterial RNA polymerase. This mechanism of action makes it a valuable tool compound for advanced microbiological research and a promising scaffold for the development of novel antibacterial agents. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in the study of bacterial transcription and the discovery of new anti-infective therapies.

Application

• Antibacterial Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) in the discovery and validation of new antibiotics targeting bacterial RNA polymerase.
• Mechanistic Studies: Used in biochemical and microbiological assays to investigate the fundamental processes of bacterial transcription and the mechanisms of antibiotic resistance.
• High-Throughput Screening (HTS): Employed as a positive control or probe in screening campaigns to identify compounds with similar or synergistic modes of action.
• Structure-Activity Relationship (SAR) Analysis: Provides a core chemical structure for medicinal chemistry programs aimed at optimizing potency, spectrum, and pharmacokinetic properties.
• Academic Research: Utilized in university and institutional labs for fundamental studies in bacteriology, molecular biology, and infectious disease.

Basic Information

Product Name	Myxopyronin B
CAS No.	88192-99-8
Molecular Formula	C31H43NO7
Molecular Weight	541.68 g/mol
Synonyms	Myxopyronin B; Antibiotic Myxopyronin B; (2E,4E,6E,8E)-9-[(2R,3S,4S,5S,6R)-4,5-Dihydroxy-3,6-dimethyloxan-2-yl]-3-[(2S,3S)-3-hydroxybutan-2-yl]-N,1,7-trimethyl-2-oxonona-2,4,6,8-tetraenamide; Myx B
EINECS	Contact for details

Quality Control

Our Myxopyronin B is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity, suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles as determined by advanced analytical techniques including HPLC, NMR, and MS. We support research integrity with full traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive) and light-sensitive; allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and exposure.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.