Description

2'-(6-Aminopurinyl-9)-4'-Hydroxymethyl-3'-Oxa-1'-Oxopentyl-5'-Diphosphate is a high-purity, modified nucleotide derivative of significant interest in advanced biochemical research and pharmaceutical development. This compound serves as a critical building block for the synthesis of novel nucleotide analogs and prodrugs, enabling targeted therapeutic strategies. It is essential for researchers and manufacturers in the fields of antiviral drug discovery, oncology research, and the development of nucleotide-based molecular probes.

Application

• Antiviral Drug Development: Key intermediate in the synthesis of nucleotide analog prodrugs targeting viral polymerases.
• Oncology Research: Used in the creation of novel chemotherapeutic agents that interfere with DNA/RNA synthesis in cancer cells.
• Biochemical Tool Synthesis: Serves as a precursor for labeled nucleotides used in sequencing, PCR, and other molecular biology techniques.
• Prodrug Design: The modified phosphate moiety is utilized to enhance cell permeability and bioavailability of active nucleotide metabolites.
• Enzyme Substrate Studies: Acts as a substrate or inhibitor for studies involving kinases, polymerases, and other nucleotide-processing enzymes.
• Pre-clinical Pharmaceutical Research: Critical for the investigation of new mechanisms of action and metabolic pathways in drug discovery pipelines.

Basic Information

Product Name	2'-(6-Aminopurinyl-9)-4'-Hydroxymethyl-3'-Oxa-1'-Oxopentyl-5'-Diphosphate
CAS No.	88169-73-7
Molecular Formula	C₁₆H₂₃N₅O₁₃P₂
Molecular Weight	579.33 g/mol
Synonyms	9-[(2-Hydroxymethyl-5-oxo-3-oxapent-1-yl)adenine] Diphosphate; 2'-Adenylyl-(5'→1')-2-hydroxymethyl-3-oxapentane-1,5-diol 5-Diphosphate; Modified Adenosine Diphosphate Derivative; 2'-C-alkoxyalkyl Adenosine 5'-Diphosphate Analog; Acyclic Nucleotide Diphosphate; ANP-DP; Prodrug Nucleotide Intermediate; 88169-73-7
EINECS	Contact for details

Quality Control

Every batch of 2'-(6-Aminopurinyl-9)-4'-Hydroxymethyl-3'-Oxa-1'-Oxopentyl-5'-Diphosphate is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality system is designed to meet the stringent requirements of research and pre-clinical development. Certificates of Analysis (COA) detailing purity (by HPLC), water content, and identification are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider under an inert atmosphere. Allow the sealed container to reach ambient temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 3.0%
Solvent Residue (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.