Description

2'-Deoxy-N2,N2-Dimethylguanosine is a chemically modified nucleoside analog of guanosine, where the 2'-hydroxyl group is absent and the exocyclic amino group on the guanine base is dimethylated. This specific modification is crucial for research into nucleic acid structure, stability, and function, as it alters base-pairing properties and resistance to enzymatic degradation. It serves as a valuable building block and reference standard for pharmaceutical R&D, particularly in the development of oligonucleotide-based therapeutics, antiviral agents, and diagnostic probes. Researchers and manufacturers in the fields of medicinal chemistry, molecular biology, and diagnostic assay development rely on this high-purity compound for advanced studies.

Application

• Oligonucleotide Synthesis: Used as a modified phosphoramidite or solid-support precursor for introducing specific, non-canonical bases into synthetic DNA strands to study structure-activity relationships.
• Medicinal Chemistry & Drug Discovery: Serves as a key intermediate in the research and development of nucleoside analog prodrugs, particularly for antiviral and anticancer applications.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies to understand the mechanisms of polymerases, nucleases, and methyltransferases.
• Diagnostic Probe Development: Utilized in the design of labeled probes and primers where altered melting temperatures or specific binding properties are required.
• Reference Standard: Provides a high-purity analytical standard for quality control and method development in pharmaceutical manufacturing and academic research.
• Antisense & siRNA Technology: Investigated for incorporation into antisense oligonucleotides or small interfering RNAs (siRNAs) to enhance stability and efficacy.

Basic Information

Product Name	2'-Deoxy-N2,N2-Dimethylguanosine
CAS No.	88127-22-4
Molecular Formula	C₁₂H₁₇N₅O₄
Molecular Weight	295.30 g/mol
Synonyms	N2,N2-Dimethyl-2'-deoxyguanosine; 2'-Deoxy-N²,N²-dimethylguanosine; dG(N2-Me2); 9-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-(dimethylamino)-1H-purin-2-one; 2'-Deoxy-N(2),N(2)-dimethylguanosine; N(2),N(2)-Dimethyl-2'-deoxyguanosine; 2'-Deoxy-N2,N2-dimethyl-guanosine
EINECS	Contact for details

Quality Control

Every batch of 2'-Deoxy-N2,N2-Dimethylguanosine is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our standard quality protocol includes HPLC for assay and purity determination, along with spectroscopic methods (NMR, MS) for structural confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all test results against established specifications. For custom synthesis or specific grade requirements (e.g., >98% HPLC purity), detailed specifications and supporting documentation are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent absorption of moisture. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.