Description

5-Fluoro-6-Iodouridine is a halogenated nucleoside analog of significant interest in pharmaceutical research and development. This compound serves as a critical building block in the synthesis of novel antiviral and anticancer agents, particularly those targeting viral polymerases and cellular DNA/RNA metabolism. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the development of nucleoside-based therapeutics. The high purity and reliable supply of this intermediate are essential for advancing cutting-edge medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of experimental antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies involving thymidine kinase and other nucleoside-metabolizing enzymes.
• Medicinal Chemistry: A versatile building block for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Antiviral Agent Development: Investigated for incorporation into oligonucleotides targeting viral replication mechanisms.
• Radiopharmaceutical Precursor: Potential starting material for iodine-123 or iodine-131 labeled compounds for diagnostic imaging or therapy.
• Life Science Reagents: Component in specialized kits and reagents for molecular biology and diagnostic assay development.

Basic Information

Product Name	5-Fluoro-6-Iodouridine
CAS No.	87818-06-2
Molecular Formula	C9H10FIN2O6
Molecular Weight	388.09 g/mol
Synonyms	6-Iodo-5-fluorouridine; 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-fluoro-6-iodopyrimidine-2,4(1H,3H)-dione; 5-Fluoro-6-iodo-1-β-D-ribofuranosyluracil; 5-Fluoro-6-iodo-1-(β-D-ribofuranosyl)uracil; 5-Fluoro-6-iodouridine; 6-Iodo-5-fluoro-1-β-D-ribofuranosyluracil
EINECS	Contact for details

Quality Control

Our 5-Fluoro-6-Iodouridine is manufactured under controlled conditions to ensure high chemical purity and batch-to-batch consistency, suitable for demanding research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry. A Certificate of Analysis (COA) detailing all test results is provided with every shipment. We adhere to a rigorous quality management system to meet the exacting standards of the pharmaceutical and biotechnology industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.