Description

N(2)-(4-n-Butylphenyl) 2'-Deoxyguanosine is a chemically modified nucleoside derivative, specifically a guanosine analog with a butylphenyl substituent at the N2 position. This structural modification is critical for imparting specific biochemical properties, making it a valuable intermediate in advanced research and development. It is primarily utilized by pharmaceutical and biotechnology companies engaged in the synthesis of novel therapeutic agents, particularly in the fields of antiviral and anticancer drug discovery. The compound's defined structure allows for precise investigation into nucleic acid interactions and enzyme inhibition mechanisms.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel nucleoside-based antiviral and anticancer prodrugs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to understand polymerase and kinase activity.
• Proteomics & Genomics: Serves as a modified base for probing DNA-protein interactions and studying nucleic acid structure and function.
• Antisense Oligonucleotide Development: Incorporated into oligonucleotide sequences to alter binding affinity and stability for therapeutic applications.
• Diagnostic Reagent Synthesis: Utilized in creating labeled probes for detection and diagnostic assays.
• Academic Research: Fundamental tool in university and institutional labs for chemical biology and medicinal chemistry projects.

Basic Information

Product Name	N(2)-(4-n-Butylphenyl) 2'-Deoxyguanosine
CAS No.	87781-96-2
Molecular Formula	C20H25N5O4
Molecular Weight	399.45 g/mol
Synonyms	N2-(4-Butylphenyl)-2'-deoxyguanosine; 2'-Deoxy-N2-(4-n-butylphenyl)guanosine; 2'-Deoxyguanosine, N2-(4-butylphenyl)-; 9-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-(4-butylphenylamino)-1H-purin-6-one; N2-(p-Butylphenyl)-2'-deoxyguanosine; dG-Butylphenyl derivative; Modified Deoxyguanosine
EINECS	Contact for details

Quality Control

Our N(2)-(4-n-Butylphenyl) 2'-Deoxyguanosine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide full traceability and Certificates of Analysis (COA) are available upon request, ensuring compliance with research and development grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.