Description

Amphotericin B-Deoxycholate CAS NO 87687-70-5 is a polyene antifungal antibiotic complex, widely recognized as the gold standard for treating severe systemic fungal infections. Its primary value lies in its broad-spectrum fungicidal activity, particularly against life-threatening pathogens like *Aspergillus* and *Candida* species. This product is essential for pharmaceutical manufacturers developing parenteral formulations, research institutions studying antifungal mechanisms, and diagnostic kit producers.

Application

• Pharmaceutical Active Ingredient (API): Core component in injectable formulations for systemic antifungal therapy.
• Hospital & Clinical Use: Used in the preparation of intravenous solutions for treating invasive fungal infections, including cryptococcal meningitis and disseminated candidiasis.
• Biomedical Research: Critical reagent for in vitro and in vivo studies on fungal pathogenicity, drug resistance mechanisms, and the development of novel antifungal agents.
• Reference Standard: Serves as a primary standard in analytical laboratories for quality control and assay calibration of antifungal products.
• Veterinary Medicine: Employed in antifungal treatments for serious fungal infections in animals.
• Microbiology & Diagnostics: Used in culture media and susceptibility testing to determine the sensitivity of fungal isolates.

Basic Information

Product Name	Amphotericin B-Deoxycholate
CAS No.	87687-70-5
Molecular Formula	C47H73NO17 • C24H40O4
Molecular Weight	924.08 g/mol (Amphotericin B) + 392.57 g/mol (Deoxycholate)
Synonyms	Amphotericin B Desoxycholate; Amphotericin B Deoxycholate Salt; Fungizone; Amphotericin B with Sodium Deoxycholate; Amphotericin B-DOC; Amphotericin B Deoxycholic Acid Complex; Amphotericin B Deoxycholate Mixture; (8E,10E,12E,14E,16E,18E,20E,22E,24E,26E,28E,30E,32E,34E)-36-(Amino-3,5-dihydroxy-6-methyloxan-2-yl)oxy-1,3,5,6,7,9,11,13,15,17,19,21,23,25,27,29,31,33,35-octadecahydroxy-36-methyloxacyclohexatriaconta-8,10,12,14,16,18,20,22,24,26,28,30,32,34-hexadecaene-2-carboxylic acid compound with deoxycholic acid
EINECS	Contact for details

Quality Control

Our Amphotericin B-Deoxycholate is manufactured under strict quality management systems. It undergoes rigorous analytical testing, including HPLC for purity and potency, to ensure compliance with relevant pharmacopeial standards (e.g., USP, EP) for pharmaceutical use. A comprehensive Certificate of Analysis (COA) detailing identity, assay, impurities, and microbiological data is provided with each batch to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	≥ 750 µg/mg (on dried basis)
Loss on Drying	≤ 5.0 %
Specific Rotation	Contact for details
Heavy Metals	≤ 20 ppm
Bacterial Endotoxins	< 5.0 EU/mg
Sterility (if applicable)	Sterile
Microbial Enumeration	Meets Ph. Eur. criteria

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.