Description

3-(2,2,2-Trifluoroacetamido)Propanoyl Chloride is a high-purity, reactive acyl chloride derivative used as a key building block in advanced organic synthesis. This compound is valued for its ability to introduce the trifluoroacetamido-propanoyl moiety, enabling the creation of novel molecules with modified properties. It is primarily utilized by research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of active pharmaceutical ingredients (APIs), bioactive compounds, and complex intermediates.

Application

• Pharmaceutical Intermediate: A critical reagent for the synthesis of novel drug candidates and active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides that require the incorporation of fluorine-containing groups for enhanced efficacy.
• Peptide & Protein Modification: Serves as an acylating agent for modifying amino acids, peptides, or proteins to introduce the trifluoroacetamido-propanoyl functional group.
• Material Science Research: Employed in the creation of specialty polymers, coatings, or advanced materials where fluorine incorporation is desired for thermal or chemical resistance.
• Fluorine Chemistry: A versatile building block in organofluorine chemistry for constructing complex molecules with tailored physical and biological properties.
• Bioconjugation & Probe Development: Useful in the synthesis of chemical probes, linkers, or labeling reagents for biochemical and diagnostic applications.

Basic Information

Product Name	3-(2,2,2-Trifluoroacetamido)Propanoyl Chloride
CAS No.	87639-76-7
Molecular Formula	C5H5ClF3NO2
Molecular Weight	203.55 g/mol
Synonyms	3-(Trifluoroacetamido)propionyl Chloride; 3-(2,2,2-Trifluoroacetamido)propionyl Chloride; N-(2-Chloro-2-oxoethyl)-2,2,2-trifluoroacetamide; 2,2,2-Trifluoro-N-(3-chloro-3-oxopropyl)acetamide; TFAP-Cl; TFA-Propanoyl Chloride; 3-(TFA-amino)Propanoyl Chloride
EINECS	Contact for details

Quality Control

Our 3-(2,2,2-Trifluoroacetamido)Propanoyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality management system is designed to meet the rigorous standards required for research and cGMP-grade chemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and highly volatile; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.