Description

5-Pyrimidinecarbonyl Chloride, 4,6-Dichloro- (9Ci) is a high-purity, reactive heterocyclic building block essential for advanced organic synthesis. This compound matters for its role as a key acyl chloride intermediate, enabling the efficient introduction of the 4,6-dichloropyrimidine-5-carbonyl moiety into target molecules. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the bioactive pyrimidine core.
• Material Science Research: Serves as a building block for creating functionalized polymers, ligands for metal-organic frameworks (MOFs), and advanced organic electronic materials.
• Chemical Biology & Proteomics: Employed in the design and synthesis of activity-based probes, affinity labels, and other molecular tools for studying biological systems.
• Custom Synthesis & Contract Manufacturing: A valuable reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	5-Pyrimidinecarbonyl Chloride, 4,6-Dichloro- (9Ci)
CAS No.	87600-97-3
Molecular Formula	C5H2Cl3N2O
Molecular Weight	211.44 g/mol
Synonyms	4,6-Dichloropyrimidine-5-carbonyl chloride; 4,6-Dichloro-5-pyrimidinecarbonyl chloride; 4,6-Dichloropyrimidine-5-carboxylic acid chloride; 5-Carboxy-4,6-dichloropyrimidine chloride; 4,6-Dichloro-5-pyrimidinecarboxylic acid chloride
EINECS	Contact for details

Quality Control

Our 5-Pyrimidinecarbonyl Chloride, 4,6-Dichloro- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.