Description

Trimethylsilylmethyl Azide is a versatile organosilicon reagent featuring a reactive azide functional group. This compound is valued for its role as a key synthon in click chemistry and cycloaddition reactions, enabling the efficient construction of complex molecular architectures. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of triazoles and other nitrogen-containing heterocycles.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of triazole-containing active pharmaceutical ingredients (APIs) via copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides that incorporate triazole moieties for enhanced biological activity.
• Polymer & Material Science: Serves as a monomer or cross-linking agent for creating functional polymers, hydrogels, and surface coatings with tailored properties.
• Bioconjugation: Facilitates the labeling and modification of biomolecules (proteins, peptides, oligonucleotides) for diagnostic and therapeutic applications.
• Organic Synthesis Reagent: Employed in [3+2] cycloadditions and other transformations to introduce the trimethylsilylmethyl and azide groups into target molecules.
• Ligand & Catalyst Development: Used to prepare novel nitrogen-donor ligands and organometallic complexes for catalytic applications.

Basic Information

Product Name	Trimethylsilylmethyl Azide
CAS No.	87576-94-1
Molecular Formula	C4H11N3Si
Molecular Weight	129.24 g/mol
Synonyms	(Azidomethyl)trimethylsilane; Trimethyl(azidomethyl)silane; Azidomethyltrimethylsilane; TMSM Azide; (Trimethylsilyl)methyl azide; N3CH2Si(CH3)3; Silane, (azidomethyl)trimethyl-
EINECS	Contact for details

Quality Control

Our Trimethylsilylmethyl Azide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, NMR, and titration, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated place at 2-8°C or as specified on the label. Due to its highly volatile and potentially shock-sensitive nature, keep away from heat, sparks, and open flames. Isolate from incompatible materials such as strong acids and reducing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.