Description

N4-Benzoyl-5’-O-(4,4’-Dimethoxytrityl)-Aracytidine is a sophisticated, protected nucleoside derivative essential for oligonucleotide synthesis. This compound serves as a critical building block in the solid-phase synthesis of DNA and RNA sequences, where it enables precise control over the genetic code. It is primarily required by research institutions, pharmaceutical developers, and biotechnology companies engaged in antisense therapy, diagnostic probe development, and synthetic biology.

Application

• Oligonucleotide Synthesis: Key phosphoramidite precursor for the automated solid-phase synthesis of DNA and RNA strands.
• Antisense Drug Development: Used in the research and production of antisense oligonucleotides for therapeutic applications targeting genetic diseases.
• Diagnostic Probe Manufacture: Essential for creating labeled probes used in PCR, sequencing, and microarray technologies.
• Synthetic Biology Research: A fundamental reagent for constructing modified nucleic acids with tailored properties.
• Academic & Pharmaceutical R&D: Employed in exploratory research to study nucleic acid structure, function, and interactions.

Basic Information

Product Name	N4-Benzoyl-5’-O-(4,4’-Dimethoxytrityl)-Aracytidine
CAS No.	87418-76-6
Molecular Formula	C38H35N3O7
Molecular Weight	645.71 g/mol
Synonyms	5’-O-DMT-N4-Benzoyl-araC; 1-β-D-Arabinofuranosyl-4-N-benzoylcytosine, 5’-O-(4,4’-dimethoxytrityl)-; DMT-araC(Bz); N4-Benzoyl-2’-deoxy-2’-fluoro-ara-cytidine 5’-DMT; Protected Aracytidine Derivative; 5’-O-(Bis(4-methoxyphenyl)phenylmethyl)-N4-benzoyl-1-β-D-arabinofuranosylcytosine
EINECS	Contact for details

Quality Control

Our production of N4-Benzoyl-5’-O-(4,4’-Dimethoxytrityl)-Aracytidine adheres to stringent in-process controls to ensure batch-to-batch consistency and high purity, suitable for sensitive oligonucleotide synthesis. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles via validated analytical methods such as HPLC and NMR. We support compliance with cGMP guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.