Description

3'-Fluoro-2',3'-Dideoxyadenosine is a chemically modified nucleoside analog, a key building block in medicinal chemistry and life science research. Its value lies in its role as a precursor for synthesizing modified oligonucleotides and potential antiviral or anticancer prodrugs, where the fluorine substitution and dideoxy backbone confer specific biological activity and metabolic stability. This high-purity intermediate is essential for pharmaceutical R&D laboratories, biotechnology companies, and academic institutions engaged in nucleoside chemistry, antiviral drug discovery, and the development of diagnostic probes.

Application

• Pharmaceutical Intermediate: Critical precursor in the synthesis of novel nucleoside-based antiviral and anticancer agents.
• Oligonucleotide Synthesis: Used as a modified phosphoramidite or solid-support building block for creating fluorinated antisense oligonucleotides or siRNAs.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies to investigate polymerase activity and nucleotide metabolism.
• Prodrug Development: A key starting material for designing prodrugs aimed at improving bioavailability and targeted delivery of nucleoside analogs.
• Diagnostic Probe Synthesis: Utilized in the creation of labeled nucleotides for molecular diagnostics and imaging applications.
• Life Science Tool: Provides a specialized scaffold for studying structure-activity relationships (SAR) in drug discovery programs.

Basic Information

Product Name	3'-Fluoro-2',3'-Dideoxyadenosine
CAS No.	87418-35-7
Molecular Formula	C10H12FN5O2
Molecular Weight	253.23 g/mol
Synonyms	3'-F-ddA; 2',3'-Dideoxy-3'-fluoroadenosine; 9-[(2R,5S)-5-Fluoro-5-(hydroxymethyl)oxolan-2-yl]purin-6-amine; 3'-Fluoro-2',3'-dideoxyadenosine; 3'-F-2',3'-ddA; Adenosine, 2',3'-dideoxy-3'-fluoro-; 3'-Fluoro-ddA
EINECS	Contact for details

Quality Control

Our 3'-Fluoro-2',3'-Dideoxyadenosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, IR, MS), to ensure it meets the high standards required for research and pharmaceutical development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.