Description

D-Proline, 1-(Chlorocarbonyl)-5-Ethyl-, trans- (9Ci) is a high-purity, non-natural amino acid derivative featuring a trans-configured ethyl substituent and a reactive chlorocarbonyl group. This compound is a critical chiral building block and intermediate in advanced organic synthesis, enabling the precise construction of complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), peptide mimetics, and other bioactive compounds.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Peptidomimetic Research: Used to introduce constrained proline analogs into peptide backbones to enhance metabolic stability and biological activity.
• Asymmetric Synthesis: Acts as a chiral auxiliary or starting material for the preparation of enantiomerically pure compounds in medicinal chemistry.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms and protein interactions.
• Agrochemical Development: Potential intermediate in the research and synthesis of novel, chiral agrochemicals.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects requiring high stereochemical fidelity.

Basic Information

Product Name	D-Proline, 1-(Chlorocarbonyl)-5-Ethyl-, trans- (9Ci)
CAS No.	87251-08-9
Molecular Formula	C8H12ClNO3
Molecular Weight	205.64 g/mol
Synonyms	(2R,5S)-5-Ethylpyrrolidine-2-carboxylic acid chloride; trans-5-Ethyl-D-proline chloride; 1-Chlorocarbonyl-trans-5-ethyl-D-proline; D-5-Ethylproline acid chloride; (2R,5S)-1-(Chlorocarbonyl)-5-ethylpyrrolidine-2-carboxylic acid; trans-1-Carboxy-5-ethyl-D-proline chloride; 87251-08-9
EINECS	Contact for details

Quality Control

Our D-Proline, 1-(Chlorocarbonyl)-5-Ethyl-, trans- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under anhydrous conditions to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.