Description

3'-Amino-2',3'-Dideoxy-5-Methylcytidine is a chemically modified nucleoside analog of significant interest in pharmaceutical research and development. This compound serves as a critical building block and intermediate in the synthesis of novel antiviral and anticancer agents, particularly in the development of nucleoside reverse transcriptase inhibitors. It is primarily utilized by research institutions, pharmaceutical companies, and fine chemical manufacturers engaged in the creation of next-generation therapeutics. The compound, with CAS number 87190-81-6, offers a specialized scaffold for probing biological mechanisms and creating targeted drug candidates.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the production of antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to understand nucleotide metabolism and polymerase function.
• Antiviral Drug Development: Serves as a core structure for designing novel compounds targeting viral reverse transcriptase and other enzymes.
• Oncology Research: Investigated for its potential to be incorporated into DNA/RNA, disrupting replication in cancer cells.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize the potency and selectivity of drug candidates.
• Process Chemistry: Used in scaling up the synthesis of active pharmaceutical ingredients (APIs) for clinical trials.

Basic Information

Item	Detail
Product Name	3'-Amino-2',3'-Dideoxy-5-Methylcytidine
CAS No.	87190-81-6
Molecular Formula	C10H16N4O4
Molecular Weight	256.26 g/mol
Synonyms	5-Methyl-3'-amino-2',3'-dideoxycytidine; 3'-Amino-2',3'-dideoxy-5-methylcytidine; 3'-Amino-5-methyl-2',3'-dideoxycytidine; 2',3'-Dideoxy-3'-amino-5-methylcytidine; 5-MethylddCyd-3'-NH2; NSC 614391; 3'-NH2-5-Methyl-ddC
EINECS	Contact for details

Quality Control

Our 3'-Amino-2',3'-Dideoxy-5-Methylcytidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.