Description

Carpetimycin D is a macrocyclic polyene antibiotic isolated from Streptomyces sp., structurally related to the nystatin and amphotericin B families. It exhibits potent antifungal activity against a broad spectrum of pathogenic yeasts and molds, making it a valuable research tool in antimicrobial mechanism studies and antifungal drug development. Researchers and pharmaceutical developers in academic laboratories, biotech R&D centers, and contract research organizations (CROs) rely on high-purity Carpetimycin D CAS NO 87139-37-5 for target validation, structure–activity relationship (SAR) profiling, and formulation feasibility studies.

Application

• Antifungal mode-of-action studies targeting ergosterol biosynthesis and membrane integrity
• In vitro screening of synergistic antifungal combinations with azoles or echinocandins
• Reference standard for HPLC and LC-MS method development and validation in antimicrobial QC labs
• Lead compound optimization in medicinal chemistry programs focused on polyene antibiotics
• Cell-based assays evaluating selective cytotoxicity against fungal versus mammalian cells
• Stability and degradation pathway analysis under controlled stress conditions (light, humidity, temperature)
• Preclinical pharmacokinetic and biodistribution studies in animal models of systemic mycosis
• Quality control reference material for fermentation-derived antifungal batches in GMP-compliant manufacturing

Basic Information

Product Name	Carpetimycin D
CAS No.	87139-37-5
Molecular Formula	C49H75NO16
Molecular Weight	926.12 g/mol
Synonyms	Carpetimycin-D; Carpetimycin D; CPD; NSC 331429; Antibiotic CP-20,473; Streptomyces sp. metabolite D; 87139-37-5; Polyene antifungal CP-20473-D; Carpetimycin D (microbial)
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. Each batch of Carpetimycin D is tested for identity (IR, HPLC retention time), assay (HPLC), related substances (HPLC), residual solvents (GC), heavy metals (USP <231>), and microbiological purity (USP <61>). Testing follows validated methods aligned with USP, EP, and ICH Q5/Q7 guidelines, supporting use in regulated preclinical research environments.

Storage

Preserve in a tightly closed container, protected from light. Store at 2–8 °C under inert atmosphere (nitrogen or argon) to prevent oxidation. Due to its hygroscopic nature, maintain low-humidity conditions (<30% RH) and minimize exposure to ambient air during handling.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Single impurity ≤ 1.0%; Total impurities ≤ 3.0%
Residual Solvents (GC)	Meets ICH Q3C limits
Water (Karl Fischer)	≤ 5.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.