Description

6-n-(4-Azido-2-Hydroxy-3,5-Diiodobenzoyl)Glucosamine is a specialized iodinated and azido-functionalized carbohydrate derivative, designed as a versatile chemical probe for advanced biochemical research. This compound matters for its unique bifunctional reactivity, where the azide group enables bioorthogonal click chemistry conjugation, and the iodine atoms provide contrast for detection and structural studies. It is primarily needed by researchers and developers in pharmaceutical R&D, chemical biology, and radiopharmaceutical precursor synthesis for labeling, imaging, and investigating carbohydrate-protein interactions.

Application

• Bioconjugation and Probe Synthesis: Acts as a key intermediate for synthesizing fluorescent, radioactive, or affinity tags via copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry.
• Glycobiology Research: Used to label and track glycosylation pathways, enzyme activity, and receptor-ligand binding studies due to its glucosamine backbone.
• Radiopharmaceutical Precursor: Serves as a potential building block for developing iodine-123 or iodine-131 labeled diagnostic and therapeutic agents.
• Material Science Functionalization: Employed to introduce bioactive carbohydrate motifs onto surfaces, nanoparticles, or polymers for creating biosensors and smart materials.
• Enzyme Inhibitor Studies: Utilized in the design and screening of inhibitors for glycosyltransferases and other carbohydrate-processing enzymes.
• Structural Biology: Aids in X-ray crystallography and cryo-EM studies by providing heavy atom derivatives (iodine) for phase determination in protein-carbohydrate complexes.

Basic Information

Product Name	6-n-(4-Azido-2-Hydroxy-3,5-Diiodobenzoyl)Glucosamine
CAS No.	86979-64-8
Molecular Formula	C13H14IN3O7
Molecular Weight	547.08 g/mol
Synonyms	4-Azido-2-hydroxy-3,5-diiodobenzoic acid 6-amino-6-deoxy-β-D-glucopyranosyl ester; 6-Azido-2-hydroxy-3,5-diiodobenzoylglucosamine; N-(4-Azido-2-hydroxy-3,5-diiodobenzoyl)glucosamine; Glucosamine, 6-N-(4-azido-2-hydroxy-3,5-diiodobenzoyl)-; Azido-diiodo-hydroxybenzoyl glucosamine; Click chemistry glucosamine probe; Iodinated azido-benzoyl glucosamine
EINECS	Contact for details

Quality Control

Our 6-n-(4-Azido-2-Hydroxy-3,5-Diiodobenzoyl)Glucosamine is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR for structural confirmation, and MS for identity verification. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. The compound is both light-sensitive and potentially hygroscopic; allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. Keep away from strong reducing agents and sources of heat or ignition.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.