Description

S-(5'-Adenosyl)-L-Methionine Chloride Dihydrochloride is a high-purity, biologically active form of the essential methyl donor S-adenosylmethionine (SAMe). This compound is critical for research and development in biochemistry and pharmacology, serving as a key cofactor in numerous enzymatic transmethylation, transsulfuration, and aminopropylation reactions. It is primarily utilized by pharmaceutical manufacturers, academic research institutions, and diagnostic kit developers for applications ranging from metabolic studies to the formulation of nutraceutical and therapeutic products.

Application

• Pharmaceutical Intermediates: Serves as a critical raw material (API starting material) in the synthesis of prescription drugs targeting liver function, osteoarthritis, and mood disorders.
• Biochemical Research: Essential as a coenzyme in enzymatic assays and studies of methylation pathways, epigenetics, and cellular metabolism.
• Nutraceutical Formulation: Used in the production of high-grade dietary supplements for supporting joint health, liver detoxification, and emotional well-being.
• Diagnostic Reagents: Incorporated into in-vitro diagnostic (IVD) kits for measuring enzymatic activity of methyltransferases in clinical samples.
• Cell Culture & Biotechnology: Applied in media supplements to study and influence cellular methylation states and gene expression in bioprocessing.

Basic Information

Product Name	S-(5'-Adenosyl)-L-Methionine Chloride Dihydrochloride
CAS No.	86867-01-8
Molecular Formula	C15H23N6O5S.Cl.2HCl
Molecular Weight	502.8 g/mol
Synonyms	S-Adenosylmethionine Chloride Dihydrochloride; SAMe Chloride Dihydrochloride; AdoMet Chloride Dihydrochloride; (2S)-2-Amino-4-[[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl-methylsulfonio]butanoate Chloride Dihydrochloride; SAM Chloride Dihydrochloride; Adenosylmethionine Chloride Dihydrochloride; L-Methionine, S-(5'-deoxyadenosin-5'-yl), chloride, dihydrochloride
EINECS	Contact for details

Quality Control

Our S-(5'-Adenosyl)-L-Methionine Chloride Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets stringent specifications for pharmaceutical and research use. Certificates of Analysis (COA) detailing purity, impurities, and other critical parameters are available upon request to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This material is hygroscopic (moisture-sensitive) and light-sensitive. For long-term stability, store under inert atmosphere or desiccant. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
pH (1% Solution)	2.0 - 4.0
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.