Description

2-Trimethylsilylbenzonitrile is a versatile organosilicon reagent featuring a benzonitrile core protected by a trimethylsilyl group. This compound is valued for its role as a key synthetic intermediate and protecting group in advanced organic synthesis, particularly in the construction of complex pharmaceutical and agrochemical molecules. It is essential for researchers and manufacturers in fine chemical, pharmaceutical, and material science industries who require high-purity, reliable building blocks for their processes.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of active pharmaceutical ingredients (APIs), especially those containing aromatic nitrile or protected phenol functionalities.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the silyl-protected group allows for selective chemical transformations.
• Material Science Precursor: Serves as a monomer or functionalization agent in the production of specialty polymers, resins, and advanced organic materials.
• Organic Synthesis Reagent: Employed in cross-coupling reactions, such as Suzuki or Stille couplings, and as a protected intermediate in multi-step synthetic routes.
• Ligand and Catalyst Development: Utilized in the preparation of novel ligands and organometallic catalysts for asymmetric synthesis and other catalytic processes.
• Research & Development: A valuable tool for academic and industrial R&D laboratories exploring new synthetic methodologies and compound libraries.

Basic Information

Product Name	2-Trimethylsilylbenzonitrile
CAS No.	86863-90-3
Molecular Formula	C10H13NSi
Molecular Weight	175.31 g/mol
Synonyms	2-(Trimethylsilyl)benzonitrile; o-(Trimethylsilyl)benzonitrile; Benzonitrile, 2-(trimethylsilyl)-; 2-Cyanophenyltrimethylsilane; TMS-Benzonitrile (ortho-); 2-TMS-benzonitrile; (2-Cyanophenyl)trimethylsilane
EINECS	Contact for details

Quality Control

Our 2-Trimethylsilylbenzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specifications and test results. Our quality commitment ensures the material meets the stringent requirements for research and commercial-scale synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.