Description

(4E,6Z)-2-Demethylnaphthomycin A is a structurally distinct derivative of the naphthomycin class of ansamycin antibiotics. This compound is valued for its role as a key intermediate and reference standard in advanced pharmaceutical research and development. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery of novel antimicrobial and antitumor agents, leveraging its unique biochemical properties for mechanism-of-action studies and lead optimization.

Application

• Pharmaceutical Research: Serves as a critical intermediate in the synthesis and development of novel ansamycin-based therapeutics.
• Antimicrobial Studies: Used as a reference standard in bioassays to evaluate activity against resistant bacterial strains.
• Oncology Research: Investigated for its potential antitumor properties and as a molecular probe in cancer signaling pathway studies.
• Biochemical Tool: Employed in enzymatic studies to understand the inhibition of bacterial RNA polymerase.
• Process Chemistry: Acts as a high-purity building block for the scalable synthesis of complex natural product derivatives.
• Analytical Standard: Provides a certified reference material for quality control and method validation in analytical laboratories.

Basic Information

Product Name	(4E,6Z)-2-Demethylnaphthomycin A
CAS No.	86825-88-9
Molecular Formula	C39H49NO10
Molecular Weight	691.81 g/mol
Synonyms	2-Demethylnaphthomycin A; Demethylnaphthomycin A; Ansamycin derivative; Naphthomycin A, 2-demethyl-; (4E,6Z)-2-Demethylnaphthomycin; Antibiotic SL 2266 derivative; 2-Desmethylnaphthomycin A
EINECS	Contact for details

Quality Control

Our (4E,6Z)-2-Demethylnaphthomycin A is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. For long-term storage, desiccate to maintain stability. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.