Description

8-Bromoguanosine 3'-Phosphate is a modified nucleotide monophosphate derivative of guanosine, featuring a bromine substitution at the 8-position of the purine ring. This specific modification makes it a valuable biochemical building block and research tool for studying nucleic acid structure, function, and enzyme interactions. It is primarily utilized by researchers and manufacturers in the fields of pharmaceutical development, molecular biology, and oligonucleotide synthesis.

Application

• Oligonucleotide Synthesis: As a modified phosphoramidite precursor for the solid-phase synthesis of oligonucleotides containing 8-bromoguanosine, used in structural and functional studies.
• Biochemical Research: As a substrate or inhibitor for enzymes such as kinases, phosphatases, and polymerases to investigate nucleotide binding and catalytic mechanisms.
• Structural Biology: For probing nucleic acid conformation and stability, as the 8-bromo modification can influence base pairing and stacking interactions.
• Antiviral & Anticancer Agent Development: Serves as a key intermediate in the research and synthesis of nucleoside analog prodrugs targeting viral replication or cellular proliferation.
• Diagnostic Probe Development: Used in the creation of labeled nucleotides for assays and detection systems in molecular diagnostics.
• Cross-linking Studies: The bromine atom can facilitate photo-crosslinking or serve as a handle for further chemical modifications in bioconjugation chemistry.

Basic Information

Product Name	8-Bromoguanosine 3'-Phosphate
CAS No.	86808-63-1
Molecular Formula	C10H13BrN5O8P
Molecular Weight	442.12 g/mol
Synonyms	8-Bromo-3'-GMP; 8-Br-GMP; 8-Bromoguanosine 3'-monophosphate; Guanosine, 8-bromo-, 3'-(dihydrogen phosphate); 8-Bromo-3'-guanosine monophosphate; 8-Br-guanosine-3'-phosphate; 8-Bromoguanosine 3'-phosphoric acid
EINECS	Contact for details

Quality Control

Our 8-Bromoguanosine 3'-Phosphate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/UV)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.