Description

8-Bromoguanosine 2'-Phosphate is a modified nucleoside monophosphate derivative, serving as a critical building block and research reagent in nucleic acid chemistry. Its primary value lies in its bromine substitution, which introduces a reactive handle for further chemical modifications and cross-linking studies. This compound is essential for researchers and manufacturers in the fields of oligonucleotide synthesis, biochemical research, and pharmaceutical development, particularly for investigating RNA structure, function, and for creating novel nucleotide analogs.

Application

• Oligonucleotide Synthesis: Used as a modified phosphoramidite precursor for the solid-phase synthesis of bromine-labeled RNA strands.
• Biochemical Research: Acts as a substrate or inhibitor in enzymatic studies involving kinases, phosphatases, and polymerases to probe nucleotide binding sites.
• Structural Biology: Incorporated into RNA for X-ray crystallography or cryo-EM studies, where the heavy bromine atom aids in phasing.
• Cross-linking Probes: The bromine atom can be utilized in photo-activatable cross-linking experiments to study RNA-protein or RNA-RNA interactions.
• Pharmaceutical Intermediate: Serves as a key synthetic intermediate in the development of nucleoside-based antiviral or anticancer prodrugs.
• Diagnostic Assay Development: Used in the creation of labeled probes for detecting specific RNA sequences in diagnostic applications.

Basic Information

Product Name	8-Bromoguanosine 2'-Phosphate
CAS No.	86808-62-0
Molecular Formula	C10H13BrN5O8P
Molecular Weight	442.12 g/mol
Synonyms	8-Bromo-guanosine 2'-monophosphate; 8-Br-GMP; 8-Bromo-GMP; 2'-GMP-8-Br; Guanosine, 8-bromo-, 2'-(dihydrogen phosphate); 8-Bromoguanosine 2'-monophosphoric acid; 8-Br-2'-GMP
EINECS	Contact for details

Quality Control

Every batch of 8-Bromoguanosine 2'-Phosphate is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality system is designed to meet the stringent requirements of research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity (typically by HPLC), identity confirmation (by NMR and MS), and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent decomposition. For long-term storage, keep containers sealed under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.