Description

Pre-Queuosine1 Dihydrochloride is a chemically modified nucleoside derivative, serving as a key intermediate in the biosynthesis of the hypermodified tRNA nucleoside queuosine. This compound matters for researchers and manufacturers as it provides a critical building block for studying and manipulating queuosine-related pathways, which are implicated in cellular translation efficiency and stress response. It is primarily needed by biotechnology firms, academic research institutions, and pharmaceutical companies engaged in nucleic acid chemistry, tRNA research, and the development of novel therapeutic agents.

Application

• Biochemical Research: As a precursor in enzymatic and chemical synthesis studies of queuosine and its analogs.
• Pharmaceutical Development: Potential use as an intermediate in the synthesis of nucleoside-based therapeutics targeting translation.
• Enzymology Studies: Substrate or inhibitor for enzymes involved in the queuosine biosynthesis pathway, such as tRNA-guanine transglycosylase (TGT).
• Microbiology & Cell Biology: Tool compound for investigating the role of queuosine modification in bacterial virulence and eukaryotic cell proliferation.
• Diagnostic Reagent Manufacturing: Component in specialized assay kits for studying tRNA modification status.

Basic Information

Product Name	Pre-Queuosine1 Dihydrochloride
CAS No.	86694-45-3
Molecular Formula	C17H27Cl2N5O8
Molecular Weight	508.33 g/mol
Synonyms	7-(((4S,5R)-4,5-Dihydroxy-2-cyclopenten-1-yl)amino)-5'-O-[hydroxy(phosphonooxy)phosphoryl]-7-deazaguanosine Dihydrochloride; 7-Cyclopentenyl-7-deazaguanosine 5'-triphosphate derivative Dihydrochloride; PreQ1 Dihydrochloride; Pre-Queuosine 1 Dihydrochloride; 7-Aminomethyl-7-deazaguanosine 5'-triphosphate precursor Dihydrochloride; tRNA Queuosine Precursor 1 Dihydrochloride
EINECS	Contact for details

Quality Control

Our Pre-Queuosine1 Dihydrochloride is produced under controlled conditions to ensure high purity and batch-to-batch consistency. Quality is verified through a comprehensive suite of analytical techniques, including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each batch to support your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic (moisture-sensitive) nature, the container should be allowed to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.