Description

Cholan-24-Amide, 3,7,12-Trihydroxy-N,n-Dimethyl-, (3α,5β,7α,12α)- is a high-purity, modified bile acid derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical synthetic intermediate and reference standard for the production of novel therapeutic agents and diagnostic tools. It is primarily utilized by research institutions, pharmaceutical manufacturers, and fine chemical suppliers focused on metabolic, hepatic, and gastrointestinal drug discovery.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel bile acid-based therapeutics targeting metabolic and liver disorders.
• Biochemical Research: Used as a reference standard and probe in studies of bile acid transport, receptor binding (e.g., FXR, TGR5), and metabolic signaling pathways.
• Diagnostic Agent Development: Serves as a precursor for developing contrast agents or radiolabeled compounds for medical imaging.
• Chemical Biology: Employed in the design and synthesis of molecular tools to study protein-ligand interactions and enzyme function.
• Fine Chemical Synthesis: A versatile chiral starting material for the preparation of complex, stereochemically defined molecules in organic chemistry.

Basic Information

Product Name	Cholan-24-Amide, 3,7,12-Trihydroxy-N,n-Dimethyl-, (3α,5β,7α,12α)-
CAS No.	86678-85-5
Molecular Formula	C₂₆H₄₅NO₄
Molecular Weight	435.64 g/mol
Synonyms	N,N-Dimethyl-3α,7α,12α-trihydroxy-5β-cholan-24-amide; 3α,7α,12α-Trihydroxy-5β-cholan-24-oic acid N,N-dimethylamide; Taurochenodeoxycholic acid dimethylamide derivative; (3α,5β,7α,12α)-3,7,12-Trihydroxy-N,N-dimethylcholan-24-amide; TCDC dimethylamide; Bile acid amide derivative; 5β-Cholan-24-amide, 3,7,12-trihydroxy-N,N-dimethyl-, (3α,5β,7α,12α)-
EINECS	Contact for details

Quality Control

Our Cholan-24-Amide, 3,7,12-Trihydroxy-N,n-Dimethyl-, (3α,5β,7α,12α)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and specific tests for residual solvents and related substances. We provide Certificates of Analysis (COA) with each shipment to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.