Description

7-Ethyl-10-Hydroxycamptothecin is a potent semi-synthetic derivative of the natural alkaloid camptothecin, belonging to the topoisomerase I inhibitor class. Its primary value lies in its role as the active pharmaceutical ingredient (API) in the development of advanced chemotherapeutic agents. This compound is critical for pharmaceutical R&D and manufacturing sectors focused on oncology treatments, particularly for targeting various solid tumors. The high-purity material is essential for ensuring the efficacy and safety of final drug formulations.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the core active component in injectable and oral anti-cancer drug formulations.
• Oncology Drug Development: Key intermediate in the research and synthesis of novel chemotherapeutic agents targeting topoisomerase I.
• Reference Standard: Serves as a high-purity analytical standard for quality control and pharmacokinetic studies in pharmaceutical laboratories.
• Biochemical Research: Used in vitro and in vivo studies to investigate mechanisms of apoptosis and cell cycle arrest in cancer cell lines.
• Preclinical Studies: Essential material for toxicity, efficacy, and biodistribution studies during the drug discovery pipeline.
• Liposomal & Nanoparticle Formulations: A candidate for advanced drug delivery system development to improve therapeutic index and reduce side effects.

Basic Information

Product Name	7-Ethyl-10-Hydroxycamptothecin
CAS No.	86639-52-3
Molecular Formula	C22H20N2O5
Molecular Weight	392.41 g/mol
Synonyms	SN-38; 7-Ethyl-10-hydroxycamptothecin; 10-Hydroxy-7-ethylcamptothecin; (S)-10-Hydroxy-7-ethylcamptothecin; Irinotecan Metabolite; CPT-11 Active Metabolite; 7-Ethyl-10-hydroxy-20(S)-camptothecin; NSC 669471
EINECS	Contact for details

Quality Control

Our 7-Ethyl-10-Hydroxycamptothecin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets stringent specifications for pharmaceutical research and development. Certificates of Analysis (COA) are provided with each shipment, detailing all test results. We support compliance with cGMP and ICH Q7 guidelines for active pharmaceutical ingredients.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or refrigerated (2-8°C) as specified for the specific grade. The container should be kept in a dry, well-ventilated area. Avoid prolonged exposure to high humidity and temperatures above 30°C.

Specification

Item	Specification
Appearance	Yellow to light yellow powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.2%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.