Description

9-(3,5-o-Phosphinylidene-D-Arabinofuranosyl)-9H-Purin-6-Amine CAS NO 86579-26-2 is a high-purity nucleoside phosphonate derivative, a key intermediate in advanced pharmaceutical synthesis. This compound is valued for its role in the development of nucleotide-based therapeutics, including antiviral and anticancer agents. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on innovative drug discovery and process development.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel nucleotide analogs and prodrugs.
• Antiviral Drug Research: Used in the development of active pharmaceutical ingredients (APIs) targeting viral polymerases.
• Oncology Research: Serves as a precursor in the creation of chemotherapeutic agents that interfere with DNA/RNA synthesis.
• Biochemical Research: Employed in enzymatic studies and as a substrate analog to investigate metabolic pathways.
• Process Chemistry: Used in scale-up and optimization of synthetic routes for nucleotide-based medicines.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical labs.

Basic Information

Product Name	9-(3,5-o-Phosphinylidene-D-Arabinofuranosyl)-9H-Purin-6-Amine
CAS No.	86579-26-2
Molecular Formula	C10H14N5O6P
Molecular Weight	331.22 g/mol
Synonyms	9-(3,5-Di-O-phosphinylidene-β-D-arabinofuranosyl)adenine; D-4'-Adenine Phosphonate; Adenine Arabinoside Phosphonate; 9H-Purin-6-amine, 9-(3,5-dihydroxy-4-phosphonatooxymethyltetrahydrofuran-2-yl)-; 9-(3,5-Di-O-phosphono-β-D-arabinofuranosyl)adenine; Ara-A Phosphonate; Contact for details on additional synonyms.
EINECS	Contact for details

Quality Control

Our 9-(3,5-o-Phosphinylidene-D-Arabinofuranosyl)-9H-Purin-6-Amine is manufactured under strict quality management systems. We offer material suitable for research and pharmaceutical development, with typical purity levels exceeding 95% (HPLC). Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each batch. Specifications can be aligned with client requirements for critical parameters such as residual solvents and related substances.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccants or an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Single Unknown Impurity	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.