Description

Guanosine 3',5'-Cyclic Monophosphorothioate, Rp-Isomer, Triethylammonium Salt is a chemically modified, non-hydrolyzable analog of cyclic GMP (cGMP) designed for advanced biochemical and pharmacological research. This compound serves as a crucial tool for selectively inhibiting cGMP-dependent protein kinases (PKG) and studying cyclic nucleotide signaling pathways. It is essential for researchers and developers in pharmaceutical discovery, molecular biology, and cardiovascular research who require precise probes to dissect complex cellular mechanisms.

Application

• Biochemical Research: As a potent and selective inhibitor of cGMP-dependent protein kinase (PKG) to study its role in smooth muscle relaxation, platelet aggregation, and neuronal signaling.
• Pharmaceutical Development: Used in target validation and screening assays for drug candidates targeting nitric oxide (NO) and natriuretic peptide signaling pathways.
• Cell Signaling Studies: Investigation of cyclic nucleotide cross-talk and the specific functions of the Rp diastereomer in modulating phosphodiesterase (PDE) activity and ion channel regulation.
• Neuroscience: Research into the role of cGMP in long-term potentiation (LTP), memory formation, and phototransduction in retinal cells.
• Cardiovascular Research: Probing the mechanisms of vasodilation, blood pressure regulation, and cardiac contractility.
• Enzyme Mechanism Studies: Serves as a substrate analog to study the specificity and kinetics of phosphodiesterases and cyclases.

Basic Information

Product Name	Guanosine 3',5'-Cyclic Monophosphorothioate, Rp-Isomer, Triethylammonium Salt
CAS No.	86562-09-6
Molecular Formula	C16H27N6O11P2S · xC6H15N
Molecular Weight	Contact for details
Synonyms	Rp-cGMPS triethylammonium salt; Guanosine 3',5'-cyclic monophosphorothioate, Rp-isomer; Rp-Guanosine 3',5'-cyclic phosphorothioate; Rp-cGMPS; 8-Rp-Guanosine 3',5'-cyclic monophosphorothioate; Cyclic GMP phosphorothioate, Rp-isomer; PKG inhibitor Rp-8-pCPT-cGMPS (related analog); Rp-8-Br-cGMPS (related analog)
EINECS	Contact for details

Quality Control

Our Guanosine 3',5'-Cyclic Monophosphorothioate, Rp-Isomer is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency suitable for sensitive research applications. Each lot undergoes rigorous analytical testing, including HPLC for purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, water content, and analytical methods is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0 %
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.