Description

Queuine is a hypermodified nucleobase analog of guanine, playing a crucial role in the post-transcriptional modification of specific tRNAs. This compound is essential for ensuring proper translational fidelity and efficiency in many organisms. It is primarily utilized in advanced biochemical research, pharmaceutical development, and as a critical reference standard in life science applications.

Application

• Biochemical Research: Used as a key substrate or inhibitor in studies of tRNA modification, translation, and cellular metabolism.
• Pharmaceutical Development: Investigated for its potential role in novel therapeutic strategies targeting translation-related disorders.
• Diagnostic Reagents: Serves as a high-purity component or calibrant in the development of diagnostic assays.
• Enzymology Studies: Essential for studying the function of queuine tRNA-ribosyltransferase and related enzymes.
• Microbiology & Nutrition: Used in research on gut microbiota and as a growth factor in defined microbial culture media.
• Reference Standard: Provides a certified standard for quality control and analytical method development in pharmaceutical and biotech industries.

Basic Information

Product Name	Queuine
CAS No.	86496-18-6
Molecular Formula	C₁₂H₁₃N₅O₄
Molecular Weight	291.26 g/mol
Synonyms	7-(((4S,5R)-4,5-Dihydroxy-2-cyclopenten-1-yl)amino)-5H-pyrrolo[3,2-d]pyrimidine-4-amine; Queuine base; Q-base; 7-(((4S,5R)-4,5-Dihydroxy-2-cyclopentenyl)amino)-5H-pyrrolo[3,2-d]pyrimidin-4-amine; Queuosine precursor
EINECS	Contact for details

Quality Control

Our Queuine is produced and tested under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data including HPLC purity, identity confirmation by spectroscopic methods, and impurity profiling. A detailed Certificate of Analysis (COA) is supplied with each batch, confirming compliance with customer specifications and relevant research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.