Description

2-Fluoro-8-Azaadenosine is a chemically modified nucleoside analog, specifically engineered as a potent adenosine deaminase (ADA) inhibitor. This compound is of significant value in pharmaceutical research and development for its role in modulating purine metabolism and immune response pathways. It is primarily sought after by researchers and manufacturers in the fields of oncology, immunology, and antiviral drug discovery, where it serves as a critical intermediate or active pharmaceutical ingredient (API).

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel nucleoside-based therapeutics.
• Biochemical Research: Tool compound for studying adenosine deaminase enzyme kinetics and inhibition mechanisms.
• Oncology Research: Investigated for its potential in cancer therapy, particularly in targeting cancers sensitive to purine analog treatments.
• Immunomodulator Development: Used in research for developing drugs that modulate immune cell function, such as for autoimmune diseases.
• Antiviral Agent Synthesis: A precursor in the development of antiviral compounds targeting viral polymerases.
• Enzyme Inhibitor Studies: Serves as a reference standard in high-throughput screening for ADA inhibitor discovery.

Basic Information

Product Name	2-Fluoro-8-Azaadenosine
CAS No.	86480-37-7
Molecular Formula	C9H11FN6O4
Molecular Weight	286.22 g/mol
Synonyms	8-Aza-2-fluoroadenosine; 2-Fluoro-8-azaadenosine; 2-Fluoroadenosine, 8-aza-; 9-β-D-Ribofuranosyl-2-fluoro-8-azapurine; 2-Fluoro-8-aza-9-β-D-ribofuranosyl-9H-purine; 2-F-8-aza-Ado; 2-Fluoro-8-azapurine riboside
EINECS	Contact for details

Quality Control

Our 2-Fluoro-8-Azaadenosine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. Certificates of Analysis (COA) are provided, detailing compliance with in-house specifications suitable for research and development use. We support cGMP standards for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider desiccants or inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.