Description

7-Deaza-2'-Deoxyguanosine is a chemically modified nucleoside analog, serving as a critical building block in nucleic acid research and development. Its unique 7-deaza modification imparts distinct properties, making it invaluable for studying DNA structure, function, and for the synthesis of oligonucleotide probes. This high-purity biochemical is essential for researchers and manufacturers in the fields of molecular biology, diagnostics, and pharmaceutical development who require reliable, high-quality raw materials for advanced applications.

Application

• Oligonucleotide Synthesis: A key monomer for the solid-phase synthesis of modified DNA and RNA strands, particularly for creating probes with altered hybridization properties.
• Antisense and siRNA Research: Used in the development of therapeutic oligonucleotides where nuclease resistance or altered binding affinity is desired.
• Structural Biology Studies: Employed to investigate DNA-protein interactions, polymerase mechanisms, and nucleic acid stability due to its modified heterocyclic base.
• Diagnostic Probe Development: Integral for manufacturing fluorescently labeled or otherwise tagged probes used in PCR, FISH, and microarray technologies.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies involving polymerases, nucleases, and other DNA-modifying enzymes.
• Pharmaceutical Intermediates: Acts as a precursor in the synthesis of novel nucleoside-based antiviral or anticancer agents.

Basic Information

Product Name	7-Deaza-2'-Deoxyguanosine
CAS No.	86392-75-8
Molecular Formula	C11H14N4O4
Molecular Weight	266.25 g/mol
Synonyms	7-Deaza-2'-deoxyguanosine; 2'-Deoxy-7-deazaguanosine; 2'-Deoxy-7-azaguanosine; 7-Cyano-7-deaza-2'-deoxyguanosine (precursor); Pyrrolo[2,3-d]pyrimidine-2,4(1H,3H)-dione, 7-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-; 7-Deaza-dG; d7G; 7-Deaza-2'-deoxyguanosine (7-deaza-dG)
EINECS	Contact for details

Quality Control

Our 7-Deaza-2'-Deoxyguanosine is manufactured under strict quality control protocols to ensure it meets the high-purity standards required for sensitive research and production applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles as determined by advanced analytical techniques including HPLC, NMR, and mass spectrometry. We are committed to providing materials suitable for use under cGMP and ISO 9001 quality management system guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the product label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach ambient temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.