Description

5-(2-Bromovinyl)Uridine is a modified nucleoside analog of significant interest in pharmaceutical and biochemical research. This compound serves as a crucial building block and intermediate in the synthesis of novel antiviral and anticancer agents, particularly those targeting viral polymerases. It is primarily utilized by research institutions and pharmaceutical companies engaged in nucleoside chemistry, medicinal chemistry, and the development of therapeutic oligonucleotides. The high-purity material is essential for ensuring reproducible results in sensitive synthetic and biological applications.

Application

• Pharmaceutical Intermediate: Key synthetic precursor for the development of antiviral and anticancer nucleoside analogs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize the efficacy and selectivity of therapeutic compounds.
• Biochemical Probe Development: Acts as a substrate or inhibitor in enzymatic studies, particularly for viral reverse transcriptases and DNA/RNA polymerases.
• Oligonucleotide Synthesis: Incorporated into modified oligonucleotides for antisense, siRNA, or aptamer research to alter binding properties or stability.
• Academic & Industrial R&D: Fundamental research tool in universities and corporate labs exploring nucleoside metabolism and drug mechanisms.

Basic Information

Product Name	5-(2-Bromovinyl)Uridine
CAS No.	86391-68-6
Molecular Formula	C11H13BrN2O6
Molecular Weight	349.14 g/mol
Synonyms	BVDU; (E)-5-(2-Bromovinyl)uridine; 1-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-[(E)-2-bromoethenyl]pyrimidine-2,4-dione; 5-(2-Bromovinyl)-1-β-D-ribofuranosyluracil; Brivudine impurity; Brivudine related compound; NSC 382089
EINECS	Contact for details

Quality Control

We supply 5-(2-Bromovinyl)Uridine to high-purity standards suitable for research and development. Our products undergo rigorous quality testing, including HPLC for purity and NMR for structural confirmation, to ensure batch-to-batch consistency and compliance with research-grade specifications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.