Description

24-Norchenodeoxycholic Acid is a synthetically modified bile acid derivative, structurally related to chenodeoxycholic acid. This compound serves as a crucial high-purity intermediate and reference standard in advanced pharmaceutical research and development. It is primarily utilized by pharmaceutical companies and contract research organizations (CROs) focused on metabolic and liver disease therapeutics.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel therapeutic agents targeting bile acid receptors.
• Biochemical Research: Used as a reference standard and tool compound for studying bile acid metabolism, transport, and signaling pathways.
• Metabolic Disease Studies: Investigated in research models for conditions like cholestasis, non-alcoholic fatty liver disease (NAFLD), and cholesterol gallstones.
• Analytical Standard: Serves as a high-purity calibrant for quantitative analysis (e.g., HPLC, LC-MS) in bioanalytical and pharmacokinetic studies.
• Enzymology: Substrate or inhibitor for studies involving enzymes of the bile acid biosynthesis pathway.
• Cell Culture & In Vitro Assays: Employed in cell-based assays to investigate the effects of modified bile acids on cell function and viability.

Basic Information

Product Name	24-Norchenodeoxycholic Acid
CAS No.	86386-61-0
Molecular Formula	C23H38O4
Molecular Weight	378.55 g/mol
Synonyms	3α,7α-Dihydroxy-5β-cholan-24-oic Acid; Norchenodeoxycholic Acid; 24-Nor-CDCA; 24-Nor-5β-cholanic acid-3α,7α-diol; 24-Norchenodeoxycholate; 24-Nor-CDCA; 5β-Cholan-24-oic acid, 3α,7α-dihydroxy-, (3α,5β,7α)-; 24-Nor-3α,7α-dihydroxy-5β-cholanic Acid
EINECS	Contact for details

Quality Control

Our 24-Norchenodeoxycholic Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided and can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C under an inert atmosphere to maximize stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.