Description

2-Azetidinecarboxylic Acid, 1-(Chlorocarbonyl)-, Methyl Ester, (S)- (9Ci) is a high-value chiral building block and activated ester derivative of (S)-Azetidine-2-carboxylic acid. This compound matters for its critical role in the synthesis of complex molecules, particularly in the development of pharmaceuticals and bioactive compounds where stereochemical integrity is paramount. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for constructing constrained peptidomimetics and novel heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors, enzyme modulators, and other active pharmaceutical ingredients (APIs).
• Peptidomimetics & Constrained Amino Acid Analogue: Used to introduce the rigid, four-membered azetidine ring into peptide backbones to enhance metabolic stability and biological activity.
• Agrochemical Research: Serves as a building block for novel herbicides, fungicides, and plant growth regulators with specific chiral configurations.
• Ligand & Catalyst Development: Employed in the preparation of chiral ligands for asymmetric catalysis and organocatalysts.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and protein function.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring high-purity, enantiomerically pure intermediates.

Basic Information

Product Name	2-Azetidinecarboxylic Acid, 1-(Chlorocarbonyl)-, Methyl Ester, (S)- (9Ci)
CAS No.	86264-77-9
Molecular Formula	C6H8ClNO3
Molecular Weight	177.59 g/mol
Synonyms	(S)-1-(Chlorocarbonyl)azetidine-2-carboxylic acid methyl ester; Methyl (S)-1-(chlorocarbonyl)azetidine-2-carboxylate; (S)-Azetidine-2-carboxylic acid, 1-(chlorocarbonyl)-, methyl ester; L-Azetidine-2-carboxylic acid, 1-(chlorocarbonyl)-, methyl ester; 1-Carboxyazetidine-2-carboxylic acid methyl ester chloride; Azetidine-2-carboxylic acid derivative; (2S)-1-(Chlorocarbonyl)azetidine-2-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our 2-Azetidinecarboxylic Acid, 1-(Chlorocarbonyl)-, Methyl Ester, (S)- is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chiral purity and chemical integrity, meeting the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.