Description

5’-o-Dmtr-3’-Deoxyuridine is a protected nucleoside derivative, a crucial building block in oligonucleotide synthesis. This compound is essential for researchers and manufacturers developing advanced nucleic acid-based therapeutics, diagnostics, and research tools. It is primarily used by the pharmaceutical, biotechnology, and life science research industries for the controlled synthesis of modified DNA and RNA sequences.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for the solid-phase synthesis of antisense oligonucleotides, siRNA, and aptamers.
• Pharmaceutical Intermediates: Serves as a critical intermediate in the production of nucleoside-based antiviral and anticancer prodrugs.
• Research & Development: Used in academic and industrial R&D for studying nucleic acid chemistry, enzyme mechanisms, and developing novel therapeutic modalities.
• Diagnostic Probe Development: Employed in the manufacture of labeled probes and primers for PCR, sequencing, and other molecular diagnostic applications.
• Modified Nucleoside Production: Acts as a starting material for the synthesis of various other 3'-modified deoxyuridine analogs.

Basic Information

Product Name	5’-o-Dmtr-3’-Deoxyuridine
CAS No.	86234-42-6
Molecular Formula	C31H32N2O8
Molecular Weight	560.60 g/mol
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-3'-deoxyuridine; 3'-Deoxy-5'-O-(4,4'-dimethoxytrityl)uridine; 3'-dU(DMT); 1-[(2R,5S)-5-[[Bis(4-methoxyphenyl)-phenylmethoxy]methyl]oxolan-2-yl]pyrimidine-2,4-dione; DMT-3'-deoxyuridine; 5'-O-DMT-3'-deoxyuridine
EINECS	Contact for details

Quality Control

Our 5’-o-Dmtr-3’-Deoxyuridine is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency suitable for sensitive oligonucleotide synthesis. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines for the production of pharmaceutical intermediates, ensuring traceability and documentation for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and strictly light-sensitive (protect from all light exposure). Allow the sealed container to reach ambient temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Solubility	Soluble in acetonitrile, DMF, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.