Description

(E)-5-(2-Carbomethoxyvinyl)-2'-Deoxyuridine is a chemically modified nucleoside analog, a key intermediate in the synthesis of advanced pharmaceutical compounds. Its unique structure, featuring a carbomethoxyvinyl group at the 5-position of the uracil ring, makes it a valuable building block for antiviral and anticancer research. This high-purity intermediate is essential for research institutions, pharmaceutical R&D departments, and fine chemical manufacturers developing next-generation therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Antiviral Research: Used in the development of compounds targeting viral polymerases, particularly for herpesviruses and other DNA viruses.
• Oncology Research: Serves as a scaffold for creating prodrugs and targeted therapies designed to inhibit cancer cell proliferation.
• Biochemical Probe Development: Utilized to create labeled or modified nucleotides for studying DNA replication and repair mechanisms.
• Medicinal Chemistry: A versatile building block for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Fine Chemical Synthesis: Employed in custom synthesis and contract manufacturing of specialized organic molecules for clinical trials.

Basic Information

Product Name	(E)-5-(2-Carbomethoxyvinyl)-2'-Deoxyuridine
CAS No.	86163-17-9
Molecular Formula	C₁₃H₁₆N₂O₇
Molecular Weight	312.28 g/mol
Synonyms	5-(2-Carbomethoxyethenyl)-2'-deoxyuridine; (E)-5-(2-Methoxycarbonylvinyl)-2'-deoxyuridine; 2'-Deoxy-5-(2-methoxycarbonylvinyl)uridine; 5-(2-Carbomethoxyvinyl)-2'-deoxyuridine; BVDU Carbomethoxyvinyl Analog; (E)-5-CMV-2'-dUrd; NSC 382487
EINECS	Contact for details

Quality Control

Our (E)-5-(2-Carbomethoxyvinyl)-2'-Deoxyuridine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and pharmaceutical development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality protocols are designed to meet the stringent requirements of our global clientele in the life sciences sector.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and purity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.