Description

L-Proline, 1-(Chlorocarbonyl)-, Ethyl Ester (9Ci) is a high-purity, protected amino acid derivative designed for advanced organic synthesis. This compound serves as a critical chiral building block, enabling the controlled introduction of proline moieties into complex molecular architectures. It is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries developing peptide-based therapeutics, enzyme inhibitors, and other bioactive molecules. The product is supplied with full traceability and quality documentation to support rigorous R&D and cGMP production processes.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of peptide-based drugs, enzyme inhibitors, and prodrugs.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate modified proline residues.
• Protease Inhibitor Development: Building block for creating inhibitors targeting proteases like prolyl oligopeptidase.
• Chemical Biology & Bioconjugation: Facilitates the site-specific labeling or modification of peptides and proteins.
• Asymmetric Synthesis: Employed as an organocatalyst precursor or chiral auxiliary in stereoselective transformations.
• Academic & Industrial R&D: Serves as a high-purity reference standard and starting material for novel compound libraries.

Basic Information

Product Name	L-Proline, 1-(Chlorocarbonyl)-, Ethyl Ester (9Ci)
CAS No.	86050-92-2
Molecular Formula	C8H12ClNO3
Molecular Weight	205.64 g/mol
Synonyms	Ethyl L-Prolinate Hydrochloride; N-Carboxy-L-proline Ethyl Ester Chloride; 1-(Chlorocarbonyl)-L-proline Ethyl Ester; L-Proline, 1-(chlorocarbonyl)-, ethyl ester; Proline, N-carboxy-, ethyl ester, hydrochloride, L-; Ethyl 1-chlorocarbonyl-L-prolinate; N-Chloroformyl-L-proline ethyl ester; (S)-1-(Chlorocarbonyl)pyrrolidine-2-carboxylic acid ethyl ester
EINECS	Contact for details

Quality Control

Our L-Proline, 1-(Chlorocarbonyl)-, Ethyl Ester (9Ci) is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and other critical parameters. We support compliance with REACH and other global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-Isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.