Description

2',5-Difluoro-1-Arabinosyluridine Monophosphate is a fluorinated nucleoside monophosphate analog, a key intermediate in the synthesis of advanced antiviral and anticancer agents. Its value lies in its role as a critical building block for the development of modified oligonucleotides and prodrugs, enabling targeted therapeutic action. This high-purity biochemical is essential for pharmaceutical R&D laboratories, biotechnology companies, and CDMOs focused on next-generation antiviral and oncology treatments.

Application

• Pharmaceutical Intermediate: Critical precursor in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Antiviral Drug Research: Used in the development of prodrugs targeting viral polymerases for diseases such as hepatitis and herpes.
• Oncology Research: Serves as a building block for antimetabolite chemotherapeutic agents that inhibit DNA synthesis in cancer cells.
• Biochemical Tool: Utilized in enzymatic studies and as a substrate analog to investigate nucleotide metabolism pathways.
• Oligonucleotide Synthesis: Incorporated into modified oligonucleotides for antisense or RNAi therapeutic applications.
• Process Development: Serves as a reference standard and key material for scaling up GMP manufacturing processes.

Basic Information

Product Name	2',5-Difluoro-1-Arabinosyluridine Monophosphate
CAS No.	85894-46-8
Molecular Formula	C9H11FN2O9P
Molecular Weight	365.17 g/mol
Synonyms	2',5-Difluoro-1-Arabinosyluridine 5'-Monophosphate; 2',5-Difluoroarabinouridine Monophosphate; 2',5-DiF-AraUMP; 1-(2-Deoxy-2,5-difluoro-β-D-arabinofuranosyl)uracil 5'-monophosphate; 2',5-Difluoro-1-β-D-arabinofuranosyluracil 5'-monophosphate; 5'-O-Phosphono-2',5-difluoroarabinouridine; NSC 382499 (Monophosphate)
EINECS	Contact for details

Quality Control

Our 2',5-Difluoro-1-Arabinosyluridine Monophosphate is manufactured under strict quality systems suitable for research and pharmaceutical development. Each batch is characterized and tested to ensure identity, purity, and consistency. We provide comprehensive analytical data including HPLC purity, NMR, and mass spectrometry confirmation. Certificates of Analysis (COA) detailing all release specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive); allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.