Description

2,2-Dimethyl-4(S)-4-Azidomethyl-1,3-Dioxalane is a high-value, chiral building block and key intermediate in organic synthesis. Its core value lies in the reactive azide functional group, which is pivotal for click chemistry applications, particularly the copper-catalyzed azide-alkyne cycloaddition (CuAAC). This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require precise, stereospecific intermediates for the development of novel active pharmaceutical ingredients (APIs), bioconjugates, and advanced materials.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of complex drug molecules, including nucleoside analogs and protease inhibitors.
• Click Chemistry Reagent: The azide group enables efficient, modular "click" reactions with alkynes for bioconjugation and polymer functionalization.
• Bioconjugation & Probe Development: Used to label biomolecules (proteins, antibodies, nucleic acids) with fluorescent dyes, affinity tags, or other functional moieties.
• Material Science: Serves as a monomer or cross-linker for creating functional polymers and hydrogels with tailored properties.
• Glycochemistry: Acts as a protected glycosyl donor or acceptor intermediate in the synthesis of complex carbohydrates and glycoconjugates.
• Agrochemical Research: Employed in the discovery and development of new, targeted crop protection agents.

Basic Information

Product Name	2,2-Dimethyl-4(S)-4-Azidomethyl-1,3-Dioxalane
CAS No.	85820-82-2
Molecular Formula	C6H11N3O2
Molecular Weight	157.17 g/mol
Synonyms	(4S)-4-(Azidomethyl)-2,2-dimethyl-1,3-dioxolane; (S)-4-(Azidomethyl)-2,2-dimethyl-1,3-dioxolane; 1,3-Dioxolane, 4-(azidomethyl)-2,2-dimethyl-, (4S)-; 2,2-Dimethyl-4(S)-4-azidomethyl-1,3-dioxolane; (S)-2,2-Dimethyl-4-azidomethyl-1,3-dioxolane; Azidomethyl Dioxolane Derivative; Chiral Azido Dioxolane
EINECS	Contact for details

Quality Control

Our 2,2-Dimethyl-4(S)-4-Azidomethyl-1,3-Dioxalane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with stringent specifications for research and production use. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, open flames, and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.