Description

8-Methyl-2'-Deoxyguanosine is a modified nucleoside analog of deoxyguanosine, featuring a methyl group at the 8-position of the purine ring. This specific structural modification makes it a valuable biochemical tool and a critical building block for oligonucleotide synthesis, particularly in the study of DNA damage, repair mechanisms, and epigenetic modifications. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in nucleic acid chemistry, oncology research, and the development of novel therapeutic agents.

Application

• Biochemical Research: Used as a standard or probe in studies investigating oxidative DNA damage, mutagenesis, and the biological consequences of specific DNA lesions.
• Oligonucleotide Synthesis: Serves as a modified phosphoramidite monomer for the solid-phase synthesis of custom DNA strands containing site-specific 8-methyl-2'-deoxyguanosine residues.
• Enzymology Studies: Employed as a substrate to study the activity and specificity of DNA repair enzymes, such as glycosylases, which recognize and excise damaged bases.
• Structural Biology: Incorporated into DNA sequences for X-ray crystallography or NMR studies to understand how base modifications alter DNA structure and protein-DNA interactions.
• Diagnostic Development: Potential use in the development of assays and sensors for detecting specific types of DNA damage or related biomarkers.
• Antiviral/Anticancer Research: Investigated as a precursor or analog in the development of nucleoside-based prodrugs targeting viral polymerases or cellular replication pathways.

Basic Information

Product Name	8-Methyl-2'-Deoxyguanosine
CAS No.	85819-69-8
Molecular Formula	C11H15N5O4
Molecular Weight	281.27 g/mol
Synonyms	8-Methyl-deoxyguanosine; 8-Methyl-2'-deoxyguanosine; 2'-Deoxy-8-methylguanosine; 8-Methylguanine deoxyriboside; dG(8-Me); 9-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-8-methyl-6,9-dihydro-1H-purin-6-one
EINECS	Contact for details

Quality Control

Our 8-Methyl-2'-Deoxyguanosine is produced under controlled conditions and undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to stringent in-house quality standards to meet the demands of the scientific community.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.