Description

(+/-)-2-Amino-7-Phosphonoheptanoic acid is a potent and selective competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor, a key target in neurological research. This compound is crucial for studying excitatory neurotransmission, neuronal plasticity, and the pathophysiology of various central nervous system disorders. It is an essential research-grade biochemical for neuroscientists, pharmacologists, and medicinal chemists working in academic, pharmaceutical, and biotechnology sectors.

Application

• Neuroscience Research: A fundamental tool for investigating the role of NMDA receptors in synaptic transmission, long-term potentiation (LTP), and long-term depression (LTD).
• Pharmacological Studies: Used to characterize and validate NMDA receptor subtypes in vitro and in vivo models to understand receptor function and signaling pathways.
• Neuroprotection Research: Employed in studies exploring excitotoxicity and potential therapeutic strategies for stroke, traumatic brain injury, and neurodegenerative diseases.
• Medicinal Chemistry: Serves as a critical reference standard and lead compound for the design and development of novel NMDA receptor modulators.
• Biochemical Assay Development: Used as a control antagonist in high-throughput screening (HTS) assays to identify new drug candidates targeting the NMDA receptor.
• Physiology & Pathology Models: Applied in animal models to dissect the contribution of NMDA receptor activity to pain perception, learning, memory, and psychiatric conditions.

Basic Information

Product Name	(+/-)-2-Amino-7-Phosphonoheptanoic acid
CAS No.	85797-13-3
Molecular Formula	C7H16NO5P
Molecular Weight	225.18 g/mol
Synonyms	AP7; 2-Amino-7-phosphonoheptanoic acid; DL-AP7; (±)-AP7; DL-2-Amino-7-phosphonoheptanoic acid; NMDA receptor antagonist AP7; (RS)-2-Amino-7-phosphonoheptanoic acid; 7-Phosphono-2-aminoberptanoic acid
EINECS	Contact for details

Quality Control

Our research-grade (+/-)-2-Amino-7-Phosphonoheptanoic acid is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and IR for structural confirmation, and elemental analysis. We provide full traceability and a detailed Certificate of Analysis (COA) with every shipment to ensure consistency and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry place. This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed under an inert atmosphere if possible to maintain long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.