Description

[3-(Trifluoromethyl)Phenoxy]Acetyl Chloride is a versatile and highly reactive organofluorine building block essential for advanced chemical synthesis. Its core value lies in the trifluoromethylphenoxy moiety, which imparts unique physicochemical properties to target molecules, enhancing their metabolic stability and lipophilicity. This intermediate is critically needed by R&D and production teams in the pharmaceutical and agrochemical industries for constructing complex active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in areas like kinase inhibitors and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, where the trifluoromethyl group improves biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals for high-performance displays.
• Polymer Modification: Employed to introduce fluorinated side chains into polymers, enhancing their chemical resistance and surface properties.
• Organic Synthesis Reagent: A crucial acylating agent for introducing the [3-(trifluoromethyl)phenoxy]acetyl group into amines and alcohols in medicinal chemistry research.
• Advanced Material Research: Used in developing novel materials with specific optical or electronic characteristics for specialized industrial applications.

Basic Information

Item	Detail
Product Name	[3-(Trifluoromethyl)Phenoxy]Acetyl Chloride
CAS No.	85630-83-7
Molecular Formula	C9H6ClF3O2
Molecular Weight	238.59 g/mol
Synonyms	2-[3-(Trifluoromethyl)phenoxy]acetyl chloride; m-(Trifluoromethyl)phenoxyacetyl chloride; 3-Trifluoromethylphenoxyacetyl chloride; α-Chloro-3-(trifluoromethyl)phenoxyacetone (related); 3-(Trifluoromethoxy)phenoxyacetyl chloride (isomeric); TFM-POACl (abbreviation); 2-Oxo-2-(3-(trifluoromethyl)phenoxy)ethyl chloride
EINECS	Contact for details

Quality Control

Our [3-(Trifluoromethyl)Phenoxy]Acetyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and titration, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and reactive acid chloride nature, the container must be kept under an inert atmosphere (e.g., nitrogen or argon) and protected from moisture to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.