Description

8-Methyl-2'-Deoxyadenosine is a modified nucleoside analog of deoxyadenosine, featuring a methyl group at the 8-position of the purine ring. This structural modification makes it a valuable biochemical tool and synthetic intermediate for research in nucleic acid chemistry and medicinal chemistry. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors for applications ranging from oligonucleotide synthesis to the development of novel therapeutic agents.

Application

• Oligonucleotide Synthesis: Used as a modified building block for the solid-phase synthesis of DNA and RNA strands to study structure-function relationships.
• Medicinal Chemistry Research: Serves as a key intermediate in the synthesis of nucleoside-based prodrugs and potential antiviral or anticancer agents.
• Biochemical Studies: Employed as a substrate or inhibitor in enzymatic assays to investigate the activity of methyltransferases, polymerases, and other nucleic acid-modifying enzymes.
• Antisense Technology: Incorporated into antisense oligonucleotides to modulate gene expression and enhance stability against nuclease degradation.
• Academic & Industrial R&D: A critical reagent for universities, research institutes, and CROs exploring novel nucleic acid architectures and drug discovery.
• Diagnostic Probe Development: Can be used in the design of labeled probes for genetic testing and molecular diagnostics.

Basic Information

Product Name	8-Methyl-2'-Deoxyadenosine
CAS No.	85562-60-3
Molecular Formula	C11H15N5O3
Molecular Weight	265.27 g/mol
Synonyms	8-Methyl-deoxyadenosine; 2'-Deoxy-8-methyladenosine; 8-Methyladenine deoxyriboside; 8-Methyl-2'-deoxyadenosine; 8-Me-dA; 9-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-8-methyl-6,9-dihydro-3H-purin-6-one
EINECS	Contact for details

Quality Control

Our 8-Methyl-2'-Deoxyadenosine is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.