Description

8-Chloro-2'-Deoxyadenosine is a halogenated nucleoside analog of significant interest in pharmaceutical research and development. This modified deoxyadenosine derivative serves as a crucial building block and a key intermediate in the synthesis of novel therapeutic agents, particularly in the field of antiviral and anticancer drug discovery. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require high-purity, specialized nucleosides for advanced synthesis programs.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of nucleoside-based antiviral and anticancer drugs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies involving DNA polymerases and other nucleoside-processing enzymes.
• Proteomics & Genomics: Employed in the development of oligonucleotide probes and primers for diagnostic applications.
• Medicinal Chemistry: Serves as a scaffold for structure-activity relationship (SAR) studies to develop new therapeutic candidates.
• Antiviral Agent Development: Investigated for its potential activity against viral pathogens by acting as a chain terminator or mutagen in viral replication.
• Labeled Compound Synthesis: A starting material for the preparation of radiolabeled or fluorescently tagged nucleosides for tracking and imaging studies.

Basic Information

Product Name	8-Chloro-2'-Deoxyadenosine
CAS No.	85562-55-6
Molecular Formula	C10H12ClN5O3
Molecular Weight	285.69 g/mol
Synonyms	8-Chloro-2'-deoxyadenosine; 8-Cl-dA; 8-Chloro-9-(2-deoxy-β-D-erythro-pentofuranosyl)-9H-purin-6-amine; 8-Chloro-2'-deoxyadenosine; 2'-Deoxy-8-chloroadenosine; 8-Chloro-2'-deoxyadenosine (8-Cl-dA); 8-Cl-2'-deoxyadenosine
EINECS	Contact for details

Quality Control

Our 8-Chloro-2'-Deoxyadenosine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment. We support compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Purity (HPLC)	≥98.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.