Description

5-Benzoyluridine is a chemically modified nucleoside derivative where a benzoyl group is attached to the uridine base. This modification is crucial for protecting specific functional groups during the complex synthesis of oligonucleotides and other nucleic acid analogs. It serves as a key building block and intermediate for researchers and manufacturers in the pharmaceutical and biotechnology sectors. The compound is essential for developing advanced therapeutics, including antisense oligonucleotides and mRNA-based technologies.

Application

• Pharmaceutical Intermediate: A critical protected intermediate in the multi-step synthesis of novel nucleoside-based active pharmaceutical ingredients (APIs).
• Oligonucleotide Synthesis: Used as a phosphoramidite precursor for the solid-phase synthesis of DNA and RNA strands, enabling research and therapeutic development.
• Antiviral & Anticancer Drug Research: Serves as a scaffold for developing prodrugs and investigating structure-activity relationships in nucleoside analog drug discovery.
• Biochemical Research: Employed in studies of RNA structure, function, and metabolism, as well as in enzyme inhibition assays.
• Diagnostic Probe Development: Acts as a modified base for creating labeled probes used in diagnostic assays and genomic research.

Basic Information

Product Name	5-Benzoyluridine
CAS No.	85372-91-4
Molecular Formula	C16H16N2O7
Molecular Weight	348.31 g/mol
Synonyms	Uridine, 5-benzoyl-; 5-O-Benzoyluridine; 2',3',5'-Tri-O-acetyl-5-benzoyluridine (precursor derivative); 5-Benzoyl-1-β-D-ribofuranosyluracil; BzUrd; N3-Benzoyluridine (common naming variant); 1-(β-D-Ribofuranosyl)-5-benzoyluracil
EINECS	Contact for details

Quality Control

Our 5-Benzoyluridine CAS NO 85372-91-4 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent controls for residual solvents and moisture content. We provide full traceability and detailed Certificates of Analysis (COA) to support your GMP and regulatory compliance needs for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.