Description

Pinacidil is a potent and selective potassium channel activator belonging to the cyanoguanidine class of compounds. This high-purity active pharmaceutical ingredient (API) is critical for research and development in cardiovascular pharmacology and smooth muscle physiology. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers. Pinacidil CAS NO 85371-64-8 is supplied under stringent quality control to ensure reliable and reproducible experimental and production outcomes.

Application

• Pharmaceutical Research & Development: As a reference standard and key intermediate in the synthesis and study of novel potassium channel modulators and vasodilators.
• Cardiovascular Pharmacology Studies: Used extensively in preclinical research to investigate mechanisms of vasodilation, hypertension, and coronary artery disease.
• Smooth Muscle Physiology Research: Employed as a tool compound to study the relaxation of vascular, bronchial, and urinary tract smooth muscle.
• Biochemical Assay Development: Serves as a critical component in high-throughput screening (HTS) assays for drug discovery targeting ATP-sensitive potassium (KATP) channels.
• Chemical Synthesis: Acts as a sophisticated building block for the preparation of more complex molecules in medicinal chemistry.
• Academic & Institutional Research: Supplied to universities and government labs for fundamental scientific studies on ion channel function and cellular signaling pathways.

Basic Information

Product Name	Pinacidil
CAS No.	85371-64-8
Molecular Formula	C13H19N5
Molecular Weight	245.33 g/mol
Synonyms	P 1134; (±)-Pinacidil; Pinacidil Monohydrate; P 1134 (Vasodilator); N"-Cyano-N-4-pyridyl-N'-1,2,2-trimethylpropylguanidine; 2-Cyano-1-[(4-pyridyl)amino]-3-(1,2,2-trimethylpropyl)guanidine; 3-(1,2,2-Trimethylpropyl)-N-(pyridin-4-yl)guanidine-2-carbonitrile
EINECS	Contact for details

Quality Control

Our Pinacidil is manufactured and tested under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.