Description

2',3'-Dideoxyguanosine is a synthetic nucleoside analog of guanosine, where the hydroxyl groups on both the 2' and 3' carbons of the ribose sugar are replaced by hydrogen atoms. This structural modification makes it a critical intermediate and reference standard in the research and development of antiviral and anticancer therapeutics. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic institutions focused on nucleoside chemistry and drug discovery. The compound's defined structure is essential for studying metabolic pathways and developing novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of nucleoside-based antiviral and anticancer drugs.
• Biochemical Research: Used as a reference standard and substrate in enzymatic studies, particularly those involving DNA polymerases and reverse transcriptases.
• Antiviral Agent Development: Serves as a core structure for researching compounds active against viruses such as HIV and hepatitis.
• Academic & Clinical Research: Employed in universities and research hospitals for mechanistic studies and preclinical investigations.
• Process Development & Scale-up: Used by CROs and CDMOs in the development and optimization of synthetic routes for active pharmaceutical ingredients (APIs).

Basic Information

Product Name	2',3'-Dideoxyguanosine
CAS No.	85326-06-3
Molecular Formula	C10H13N5O3
Molecular Weight	251.24 g/mol
Synonyms	2',3'-Dideoxyguanosine; ddG; 9-[(2R,5S)-5-(Hydroxymethyl)oxolan-2-yl]-1,9-dihydro-6H-purin-6-one; 2',3'-Dideoxy-Guanosine; Dideoxyguanosine; NSC 614312; Guanosine, 2',3'-dideoxy-
EINECS	Contact for details

Quality Control

Our 2',3'-Dideoxyguanosine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide comprehensive Certificates of Analysis (COA) with each shipment to ensure traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption, which may affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.