Description

Di-tert-Butylsilyl Bis(Trifluoromethanesulfonate) is a highly reactive silylating agent and a powerful electrophile used in organic synthesis. This compound matters for its exceptional ability to introduce the bulky di-tert-butylsilyl protecting group, offering superior steric protection for sensitive functional groups like alcohols and diols under mild conditions. It is critically needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures where precise and robust protection-deprotection strategies are required.

Application

• Protecting Group Chemistry: Selective protection of primary and secondary alcohols, phenols, and 1,2- or 1,3-diols in complex molecule synthesis.
• Pharmaceutical Intermediate Synthesis: Key reagent in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for nucleosides, steroids, and polyketide-derived drugs.
• Agrochemical Development: Used in creating advanced pesticide and herbicide intermediates that require stable, sterically hindered protecting groups.
• Natural Product Synthesis: Essential for the total synthesis of complex natural products like macrolides and polyethers, where chemoselectivity is paramount.
• Polymer & Material Science: Silylation agent for modifying surface properties of silica or other oxides, and in the synthesis of specialized silicone-based polymers.
• Process Chemistry & Scale-up: Employed in kilogram-scale manufacturing processes due to its predictable reactivity and the stability of the resulting silyl ethers.

Basic Information

Item	Detail
Product Name	Di-tert-Butylsilyl Bis(Trifluoromethanesulfonate)
CAS No.	85272-31-7
Molecular Formula	C10H18F6O6S2Si
Molecular Weight	440.44 g/mol
Synonyms	Di-tert-butylsilyl bis(triflate); DTBS bis(triflate); Di-tert-butylsilyl ditriflate; Di-tert-butylsilyl bis(trifluoromethanesulphonate); Bis(trifluoromethanesulfonato)di-tert-butylsilane; (Trifluoromethanesulfonato-O)di-tert-butylsilane; DTBS(OTf)2; Di-tert-butylsilyl trifluoromethanesulfonate
EINECS	Contact for details

Quality Control

Our Di-tert-Butylsilyl Bis(Trifluoromethanesulfonate) is manufactured under strict quality control protocols to ensure high chemical purity and batch-to-batch consistency, critical for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay purity and impurity profiles. Our quality system is designed to meet the stringent requirements of research and development as well as cGMP-compliant production environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature and reactivity as a strong acid/organic solvent, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.