Description

n-(tert-Butoxycarbonyl)Phosphoramidic Acid Diethyl Ester is a key organophosphorus building block and reagent used in synthetic organic chemistry. This compound is valued for its role as a protected phosphoramidate intermediate, enabling the controlled introduction of phosphorus and nitrogen functionalities. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of complex molecules, including nucleotide analogs and bioactive compounds.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of nucleotide analogs, prodrugs, and other active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides that incorporate phosphoramidate motifs.
• Peptide & Oligonucleotide Chemistry: Serves as a reagent for the modification and protection of amino acids and nucleotides during solid-phase and solution-phase synthesis.
• Chemical Biology Research: Employed in the development of enzyme inhibitors, probes, and other tools for studying biological pathways.
• Process Chemistry & Scale-up: Used in route development and optimization for the commercial manufacturing of fine chemicals.
• Academic & Industrial R&D: A versatile reagent for methodological development and the discovery of new synthetic transformations in organophosphorus chemistry.

Basic Information

Product Name	n-(tert-Butoxycarbonyl)Phosphoramidic Acid Diethyl Ester
CAS No.	85232-02-6
Molecular Formula	C9H20NO5P
Molecular Weight	253.23 g/mol
Synonyms	Diethyl (N-Boc)phosphoramidate; Diethyl (tert-Butoxycarbonyl)phosphoramidate; (Boc-NH)PO(OEt)2; Phosphoramidic acid, N-[(1,1-dimethylethoxy)carbonyl]-, diethyl ester; N-Boc-diethyl phosphoramidate; tert-Butyl (diethoxyphosphoryl)carbamate; Diethyl N-(tert-butoxycarbonyl)phosphoramidate
EINECS	Contact for details

Quality Control

Our n-(tert-Butoxycarbonyl)Phosphoramidic Acid Diethyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive analytical data, including HPLC purity, NMR, and IR spectroscopy for identity confirmation. Certificates of Analysis (COA) detailing all specifications are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.